Royal Air Force Typhoon jets have joined forces with French warplanes in a coordinated attack targeting an hidden munitions depot in Syria operated by the IS group, according to the British defence ministry.
The facility, located using surveillance, was assessed as housing weapons and explosive materials, the release indicated, and was located in mountains just to the north of Palmyra in central Syria.
"Our fighter planes employed Paveway IV guided bombs to hit a several access tunnels leading to the facility... early reports indicate the target was engaged successfully," the MoD said.
There was no sign of any harm to civilians in the strike late on Saturday and every plane involved returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - also known as the so-called Islamic State - imposed extremist governance over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This strike demonstrates British leadership, and commitment to work closely with our allies, to eliminate any revival of Daesh and their harmful and extremist ideologies in the region," UK Defence Secretary the Defence Secretary said.
British military aircraft have performed surveillance missions over Syria to "forestall any efforts to regroup" of IS subsequent to its defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank the personnel of British forces who took part in this mission for their expertise and their valour," the Defence Secretary added. "Including them were numerous UK service members on duty over Christmas and New Year. This operation, to remove terrorist threats who endanger our safety, shows how UK forces are always on standby, all year round, ensuring Britain's security domestically and influential overseas."
During December, the United States armed forces conducted what it called a "major assault" targeting Daesh sites in Syria, following an attack claimed the lives of two American soldiers and a local interpreter in Palmyra.
The UN reports Islamic State still maintains between 5,000 and 7,000 combatants in Iraq and Syria.
