Micky van de Ven Brace Halts Everton's Run at Brand New Stadium
The Dutch defender emerged as the initial backline player to net two goals in a Premier League match for Tottenham since the Belgian defender in March 2013.
Match summary
The Spurs defender nods into the net two times in opening period
Everton's Jake O'Brien has equalizer ruled after video check
Senegalese midfielder scores final goal in dying moments
The defeat is Everton's first at Hill Dickinson Stadium
Micky van de Ven found the net twice as Tottenham extended their winning streak on the road in the top division and delivered the Toffees their first defeat at their new home.
Everton were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman struck on two occasions from corners in the opening 45 minutes to place their strong form at jeopardy, and they were unable to turn it around before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
The Everton defender believed he had equalized the tally five minutes after Van de Ven's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of chances, while Vicario made a succession of excellent saves to guarantee Tottenham went five away games unbeaten in the Premier League.
But the video assistant referee intervened, advising Craig Pawson to review the score on the screen and the referee ruled that Jack Grealish and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win elevates Thomas Frank's team up to third in the division, a handful of points off north London rivals and table-toppers the Gunners.
Everton stay in 14th position and are half a dozen points ahead of the relegation zone.
Tottenham analysis: Van de Ven excels in duties at each end of pitch
Following a drab midweek performance in the Champions League against Monaco, where they mustered a only two shots on goal, Frank opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The summer signing was failed to influence the game before being substituted for Richarlison after an hour on the pitch, but it turns out he proved unnecessary in the end.
Centre-back the Dutchman converted into an offensive threat to be reckoned with.
Spurs' first goal came from a cleverly executed corner routine, with the midfielder directing the ball back across the six-yard box for an free the defender to score.
And Ven de Ven - stepping up as captain in the Argentine's unavailability - notched his second in added time as he outjumped Jordan Pickford to nod in.
Van de Ven was just as outstanding in defensive duties, partnering effectively with his defensive colleague as the pair dealt superbly with the numerous deliveries sent their way by Everton.
Toffees breakdown: Toffees lacking striker's instinct
Everton's new home had been a fortress, but it seems the novelty may have faded slightly and fans headed to the gates after the midfielder's third for Tottenham.
The break in Everton's unbeaten home run won't be a massive concern for the manager, but their attacking woes will be.
Beto and the other striker - the Toffees' two established centre-forwards - had netted just a single goal between them before Sunday's outing.
And they were unable to contribute to that miserable tally on a damp and dreary night on in Liverpool.
The striker's performance was epitomized when he opted to bicycle-kick a golden opportunity from near the goal, even with having space and time to readjust for a simpler shot that would have challenged the keeper.
Barry, too, failed to make an impact after coming on for Beto in the second half.
It was not for a shortage of chance. The majority of Everton's attacks came through the winger and Ndiaye, who relentlessly delivered dangerous crosses into the Spurs box.
What next for these two sides?
Everton: Moyes' men head to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their next round League Cup match against the Magpies.